Oxygen sensing, hypoxia-inducible factors, and disease pathophysiology.

By G. Semenza. Annual Review of Pathology, 2014

1,086 citations recorded by the source corpus.

Subfields: Cancer Research, Genetics, Pulmonary and Respiratory Medicine

View Paper: https://www.semanticscholar.org/paper/712e7969fc3be67199177acbf680ffc09efc7ee1

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cancer Research

1. V. Nizet
2. Yongqian Shu
3. Ke Wei
4. A. Palazón
5. Xinming Jing
6. Richard J. Johnson
7. C. Shao
8. L. Gray

In Genetics

1. A. Palazón
2. Richard J. Johnson
3. Ananda W. Goldrath
4. V. Nizet

In Pulmonary and Respiratory Medicine

1. L. Gray
2. Sean C. Tompkins
3. E. Taylor

Citations in the corpus

• Regulation of pyruvate metabolism and human disease (2013, background): “In regards to pyruvate metabolism, HIF1 regulates factors involved in glycolysis as well as PDK1, MCT4, and LDHA [150, 151].”
• HIF Transcription Factors, Inflammation, and Immunity (2014, background): “Limited O 2 availability results in a decrease of PHD-and FIH-dependent HIF-a hydroxylation, leading to its stabilization and nuclear translocation (Figure 1A; Semenza, 2014).”
• Role of hypoxia in cancer therapy by regulating the tumor microenvironment (2019, background): “HIF-1α can also intervene in the expression of enzymes that polymerize and regulate the alignment of collagen fibers and activity of integrins to promote cancer migration [23].”