Bacterial translocation (BT) in cirrhosis

By R. Wiest, G. Garcia‐Tsao. Hepatology, 2005

667 citations recorded by the source corpus.

Subfields: Epidemiology, Hepatology, Infectious Diseases

View Paper: https://www.semanticscholar.org/paper/ccb1a852d9d89775474668965ed9f269705df50e

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Citations in the corpus

Promotion of Hepatocellular Carcinoma by the Intestinal Microbiota and TLR4 (2012, background): “…components termed pathogen-associated molecular patterns (PAMPs) triggers inflammatory responses through Toll-like receptors (TLRs) in both early and late disease stages (Dolganiuc et al., 2007; Fukui et al., 1991; Nolan and Leibowitz, 1978; Seki et al., 2007; Wiest and Garcia-Tsao, 2005).”
Hepatic encephalopathy. (2009, background): “Infection/ inflammation have been shown to be associated with development and progression of HE in acute liver failure.(61,62) Approximately 25% of patients with acute liver failure have hyponatremia, which is more prominent in those with severe encephalopathy.”
Probiotics and immunity (2009, background): “Both mechanisms represent the rationale for the use of probiotics to prevent major complications of liver cirrhosis such as the development of a hyperdynamic circulatory state or spontaneous bacterial peritonitis, with the former being the background for the establishment of portal hypertension.(150”
EASL Clinical Practice Guidelines for the management of patients with decompensated cirrhosis. (2018, background): “induced by increased intestinal permeability and gut bacterial overgrowth observed in cirrhosis [239].”
So depression is an inflammatory disease, but where does the inflammation come from? (2013, neutral): “An increased permeability of the gut wall may allow poorly invasive gram negative bacteria to translocate into the mesenteric lymph nodes (MLNs) and sometimes into the systemic circulation [148,149].”
Enteric Dysbiosis Associated with a Mouse Model of Alcoholic Liver Disease (2010, background): “Bacterial translocation, defined as the passage of viable endogenous bacteria or their products from the intestinal tract through the epithelial mucosa to the mesenteric lymph nodes, systemic circulation, or extraintestinal organs, is considered an important mechanism for the incidence of infections”