Exploring the sequence space for tetracycline-dependent transcriptional activators: novel mutations yield expanded range and sensitivity.
By S. Urlinger, U. Baron, Marion Thellmann, M. T. Hasan, H. Bujard, W. Hillen. Proceedings of the National Academy of Sciences of the United States of America, 2000
969 citations recorded by the source corpus.
Subfields: Genetics, Molecular Biology
View Paper: https://www.semanticscholar.org/paper/ccad6f8c9c7cd953aa42f2cdc8f83fadcd54abb8
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In Genetics
In Molecular Biology
- Bosiljka Tasic
- Ed Boyden
- Fritjof Helmchen
- Hongkui Zeng
- A. Nagy
- Susan Sunkin
- D. Lagace
- Matteo Carandini
Citations in the corpus
- Visualization and genetic manipulation of adult neurogenesis using transgenic mice (2011, methodology): “bi-transgenic mice were made using a modified reverse tTA (rtTA-M2) system, also called the Tet-ON system, which as its name suggests is activated in the presence of doxycycline (Urlinger et al., 2000).”
- Transgenic mice for intersectional targeting of neural sensors and effectors with high specificity and performance (2015, positive): “…been used in mice for inducible expression of genes from the TRE (tetracycline response element, also called tetO) promoter in response to tTA (Tet-Off) or rtTA (Tet-On) activation (Garner et al., 2012; Gossen and Bujard, 1992; Mayford et al., 1996; Reijmers et al., 2007; Urlinger et al., 2000).”