Microglial activation and increased microglial density observed in the dorsolateral prefrontal cortex in autism.

By John T. Morgan, Gursharan Chana, C. Pardo, C. Achim, K. Semendeferi, Jody Buckwalter, Eric Courchesne, I. Everall. Biological Psychiatry, 2010

718 citations recorded by the source corpus.

Subfields: Cognitive Neuroscience, Developmental Neuroscience, Neurology

View Paper: https://www.semanticscholar.org/paper/cc9456c228d7f9232c55c8df33678fcca9462b4a

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cognitive Neuroscience

1. C. V. von Bartheld
2. Jami Bahney
3. H. Won
4. Jason L. Stein
5. Luis de la Torre-Ubieta
6. S. Herculano‐Houzel
7. Marion Leboyer
8. Daniel H. Geschwind

In Developmental Neuroscience

1. S. Herculano‐Houzel
2. Beth Stevens
3. C. V. von Bartheld
4. B. Barres
5. Jami Bahney
6. M. Sofroniew

In Neurology

1. B. Barres
2. Beth Stevens
3. S. Herculano‐Houzel
4. Daniel H. Geschwind
5. A. Stephan
6. M. Sofroniew
7. N. J. Allen
8. M. Pekny

Citations in the corpus

• Autism risk factors: genes, environment, and gene-environment interactions (2012, background): “Another study consistently reported microglial activation in the dorsolateral prefrontal cortex in brains of patients with ASD.68 This neuroglial response may result from either a primary disturbance of neuroglial function or unknown factors that disturb prenatal or postnatal CNS development.”
• High intelligence: A risk factor for psychological and physiological overexcitabilities (2018, background): “The brain areas that showed hyperproliferation in white matter also revealed inflammation and increased production of proinflammatory and anti-inflammatory cytokines by neuroglia was found (Morgan et al., 2010).”
• The Search for True Numbers of Neurons and Glial Cells in the Human Brain: A Review of 150 Years of Cell Counting (2016, background): “…diseases including autism spectrum disorders, mood disorder, depression, schizophrenia, and Alzheimer’s disease (Rajkowska, 2000; Cotter et al., 2001; Hof et al., 2003; Vostrikov et al., 2007; Morgan et al., 2010; Karlsen and Pakkenberg, 2011; Andrade-Moraes et al., 2013; Verkhratsky et al., 2014).”
• Advancing the understanding of autism disease mechanisms through genetics (2016, positive): “Neuropathological and positron emission tomography (PET) imaging studies have identified microglial infiltration and activation in the frontal, prefrontal, cingulate, frontoinsular and visual cortices and in the cerebellum 217–220 .”
• The complement system: an unexpected role in synaptic pruning during development and disease. (2012, background): “…tissue have suggested that abnormal microglial function and/or complement cascade activation may play a role in autism and psychiatric disorders such as schizophrenia (Pardo et al. 2005, Vargas et al. 2005, Hashimoto 2008, Monji et al. 2009, Chen et al. 2010, Morgan et al. 2010, Havik et al. 2011).”