Neurorestorative therapies for stroke: underlying mechanisms and translation to the clinic
By Zhenggang Zhang, Michael Chopp. Lancet Neurology, 2009
612 citations recorded by the source corpus.
Restorative cell-based and pharmacological therapies for experimental stroke substantially improve functional outcome. These therapies target several types of parenchymal cells (including neural stem cells, cerebral endothelial cells, astrocytes, oligodendrocytes, and neurons), leading to enhancement of endogenous neurogenesis, angiogenesis, axonal sprouting, and synaptogenesis in the ischaemic brain. Interaction between these restorative events probably underpins the improvement in functional outcome. This Review provides examples of cell-based and pharmacological restorative treatments for stroke that stimulate brain plasticity and functional recovery. The molecular pathways activated by these therapies, which induce remodelling of the injured brain via angiogenesis, neurogenesis, and axonal and dendritic plasticity, are discussed. The ease of treating intact brain tissue to stimulate functional benefit in restorative therapy compared with treating injured brain tissue in neuroprotective therapy might more readily help with translation of restorative therapy from the laboratory to the clinic.
Subfields: Cellular and Molecular Neuroscience, Developmental Neuroscience, Genetics
View Paper: https://www.semanticscholar.org/paper/cc7a85805c68e4b6f8951b40c0e1ea780d7b73b7
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In Cellular and Molecular Neuroscience
In Developmental Neuroscience
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Citations in the corpus
- Astrocyte reactivity and reactive astrogliosis: costs and benefits. (2014, background): “, by secreting vascular endothelial growth factor (VEGF), which stimulates formation of new blood vessels as well as synaptogenesis (20, 274), or by secretion of synaptogenic thrombospondin (45).”