Chris Lipinski discusses life and chemistry after the Rule of Five.

By Christopher A. Lipinski. 2003

69 citations recorded by the source corpus.

Subfields: Computational Chemistry & Drug Discovery

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In Computational Chemistry & Drug Discovery

1. C. K. Surratt
2. Gerhard Klebe
3. Chi‐Yuan Wu
4. Jeffry D. Madura
5. L. Benet
6. Michael J. Wasko
7. Kendy A. Pellegrene

Citations in the corpus

• A Role for Fragment-Based Drug Design in Developing Novel Lead Compounds for Central Nervous System Targets (2015, background): “Still, Christopher Lipinski has stated that Pfizer would not pursue compounds that broke two of the five parameters (19).”
• Virtual ligand screening: strategies, perspectives and limitations (2006, background): “Unlike the professed opinion that in docking the geometry problem has been resolved to a sufficient extent, and that the scoring problem remains an open question [120,121], it appears that both are intimately related.”
• Predicting Drug Disposition via Application of BCS: Transport/Absorption/ Elimination Interplay and Development of a Biopharmaceutics Drug Disposition Classification System (2004, background): “Lipinski has noted that the Rule of 5 was intended as a very crude filter (24).”