Antibiotic-resistant bugs in the 21st century--a clinical super-challenge.

By C. Arias, B. Murray. New England Journal of Medicine, 2009

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Antibiotics and Bacterial Resistance in the 21st Century (2014, background): “inhibiting classes, Theravance’s TD-1792 (86), in phase II trials, is a cephalosporin/glycopeptide hybrid.”
Antibiotic resistance gene spread due to manure application on agricultural fields. (2011, background): “Introduction The spread and evolution of antibiotic resistance genes, and their acquisition by bacterial pathogens is becoming one of the most important clinical challenges [1].”
Diverse and abundant antibiotic resistance genes in Chinese swine farms (2013, background): “1C), we do not expect significant phenotypic resistance to vancomycin because detection levels were low and resistance is dependent on multigene van operons (1, 25), which we did not detect.”
Development and Use of Personalized Bacteriophage-Based Therapeutic Cocktails To Treat a Patient with a Disseminated Resistant Acinetobacter baumannii Infection (2017, background): “acquiring and maintaining multiple genetic elements encoding antimicrobial resistance 66 determinants (4-6).”