Copper homeostasis and neurodegenerative disorders (Alzheimer's, prion, and Parkinson's diseases and amyotrophic lateral sclerosis).

By E. Gaggelli, H. Kozłowski, D. Valensin, G. Valensin. Chemical Reviews, 2006

1,622 citations recorded by the source corpus.

Subfields: Molecular Biology, Nutrition and Dietetics, Physiology

View Paper: https://www.semanticscholar.org/paper/cbcdf854c4a3a9d6688906a63f6f63b394db7b33

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In Molecular Biology

1. Todd R. Golub

Citations in the corpus

• Copper in diseases and treatments, and copper‐based anticancer strategies (2009, background): “Copper has also been reported to play a role in the pathogenesis of neurodegenerative diseases, including amyotrophic lateral sclerosis (ALS), AD, and the prion-mediated encephalopathies.(93) Genetic disorders of the proteins involved in the copper machinery have long been known, and related disease”
• Copper induces cell death by targeting lipoylated TCA cycle proteins (2022, background): “Genetic variation in copper homeostasis results in life-threatening disease (39, 40), and both copper ionophores (11, 17, 41, 42) and copper chelators (43–46) have been suggested as anticancer agents.”