Increased hippocampal activation in mild cognitive impairment compared to normal aging and AD

By Bradford C. Dickerson, David H. Salat, Douglas N. Greve, E. Chua, Erin Rand-Giovannetti, Dorene M. Rentz, Lars Bertram, K. Mullin, Rudolph E. Tanzi, Deborah Blacker and 2 more. Neurology, 2005

886 citations recorded by the source corpus.

Subfields: Cognitive Neuroscience, Physiology, Psychiatry and Mental health

View Paper: https://www.semanticscholar.org/paper/cb82d1b6baf9378bc705a7a4e79e5291fc750338

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Citations in the corpus

Brain imaging in Alzheimer disease. (2012, background): “Interestingly, several fMRI studies have reported evidence of increased MTL activity in at-risk subjects, particularly among very mild MCI subjects (Dickerson et al. 2004, 2005; Celone et al. 2006; Hamalainen et al. 2006; Heun et al. 2007; Kircher et al. 2007; Lenzi et al. 2009), and cognitively…”
High-resolution structural and functional MRI of hippocampal CA3 and dentate gyrus in patients with amnestic mild cognitive impairment (2010, background): “Previous studies of MCI patients have noted elevated BOLD fMRI signals in the hippocampus and parahippocampal gyrus during a variety of memory tasks (Celone et al., 2006; Dickerson et al., 2005; Hamalainen et al., 2007; Johnson et al., 2006), as noted above, although none of the studies localized th”
Activity Dependent Degeneration Explains Hub Vulnerability in Alzheimer's Disease (2012, background): “Excessive hippocampal activity is related to cortical thinning in nondemented elderly persons, is present in MCI patients, and is related to neurodegeneration in AD [49,65,66].”
Amyloid deposition is associated with impaired default network function in older persons without dementia (2009, positive): “This finding is consonant with our previous studies and those of other groups reporting hippocampal hyperactivation in very mild MCI subjects (Celone et al., 2006; Dickerson et al., 2005; Kircher et al., 2007; Miller et al., 2007) and in subjects at genetic risk for AD (Bondi et al.”
Detection of cortical thickness correlates of cognitive performance: Reliability across MRI scan sessions, scanners, and field strengths (2008, background): “, 2000b), others demonstrate its importance in delayed recall (Rodrigue and Raz, 2004; Dickerson et al., 2005).”
Critical role of soluble amyloid-β for early hippocampal hyperactivity in a mouse model of Alzheimer’s disease (2012, background): “In humans with AD, there is also evidence for early functional magnetic resonance (fMRI) hyperactivation of the hippocampus, which is followed by hypoactivity at later disease stages (36, 37).”
Impairment and compensation coexist in amnestic MCI default mode network (2010, positive): “Because MCI patients are a heterogeneous population, inconsistencies have been observed in MTL activation during memory tasks (Machulda et al., 2003; Dickerson et al., 2004, 2005). tivity in the left lateral PFC (x=−42, y=17, z=51, t=5.45), dorsal MPFC (x=−4, 38, z=−1, t=5.05) was observed in aMCI…”
A network dysfunction perspective on neurodegenerative diseases (2006, background): “Radiological imaging studies in patients with MCI have identified hyperactivation of hippocampal and neocortical regions that become hypoactive and atrophic with the progression to A”
The Cortical Signature of Alzheimer's Disease: Regionally Specific Cortical Thinning Relates to Symptom Severity in Very Mild to Mild AD Dementia and is Detectable in Asymptomatic Amyloid-Positive Individuals (2008, background): “…that described above (details have been previously published as cited below), with 39 participants in Sample 2 (Atri et al. 2005), 41 participants in Sample 3 (Wright, Dickerson, et al. 2007; Wright, Feczko, et al. 2007), and 40 participants in Sample 4 (Dickerson et al. 2005; Celone et al. 2006).”