Incidence of Adenocarcinoma of the Esophagus among White Americans by Sex, Stage, and Age

By L. Brown, S. Devesa, W. Chow. Journal of the National Cancer Institute, 2008

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Rapid increases in the incidence of adenocarcinoma of the esophagus have been reported among white men. We further explore the temporal patterns among white individuals by sex, stage, and age by use of data from the Surveillance, Epidemiology, and End Results program for 22,759 esophageal cancer cases, of which 9,526 cases were adenocarcinoma, diagnosed from January 1, 1975, through December 31, 2004. Among white men, increases in the incidence of esophageal cancer were largely attributed to the 463% increase in the incidence of adenocarcinoma from 1.01 per 100,000 person-years in 1975−1979 to 5.69 per 100,000 person-years in 2000−2004 (95% confidence intervals [CI]=0.90 to 1.13 and 5.47 to 5.91, respectively). A similar rapid increase is now clearly apparent among white women, among whom the adenocarcinoma rate increased 335% from 0.17 to 0.74 per 100,000 person-years (95% CI= 0.13 to 0.21 and 0.67 to 0.81, respectively) over the same time period. Adenocarcinoma rates rose among white men and women regardless of stage and age groups, indicating that these increases are real and not an artifact of surveillance.

Subfields: Pulmonary and Respiratory Medicine, Surgery

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