Two FOXP3+CD4+ T cell subpopulations distinctly control the prognosis of colorectal cancers

By Takuro Saito, H. Nishikawa, H. Wada, Yuji Nagano, D. Sugiyama, K. Atarashi, Y. Maeda, M. Hamaguchi, Naganari Ohkura, E. Sato and 12 more. Nature Medicine, 2016

790 citations recorded by the source corpus.

Subfields: Immunology, Oncology

View Paper: https://www.semanticscholar.org/paper/cb384b5799e0a6b0bd0756b3a7080d24b47545cc

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Immunology

1. Atsushi Tanaka
2. Naganari Ohkura
3. J. Wing
4. K. Ichiyama
5. N. Mikami
6. Shimon Sakaguchi
7. Alexander Y. Rudensky

In Oncology

1. Atsushi Tanaka
2. Shimon Sakaguchi

Citations in the corpus

• Revisiting the role of CD4+ T cells in cancer immunotherapy—new insights into old paradigms (2020, background): “These tumourinfiltrating Tregs consisted of a FoxP3hi population suppression-competent population, and a second poorly suppressive FoxP3lo population that was induced by the TH1-polarising cytokine IL-12 and that also secreted the pro-inflammatory cytokines IFNγ and IL-17 [65].”
• Regulatory T Cells and Human Disease. (2020, background): “The results indicate the contribution of cancer tissue microenvironments, especially microbial inflammation, to local composition of FOXP3+ subpopulations (145).”