Regulation of cellular iron metabolism
By Jian Wang, Kostas Pantopoulos. Biochemical Journal, 2011
1,003 citations recorded by the source corpus.
Iron is an essential but potentially hazardous biometal. Mammalian cells require sufficient amounts of iron to satisfy metabolic needs or to accomplish specialized functions. Iron is delivered to tissues by circulating transferrin, a transporter that captures iron released into the plasma mainly from intestinal enterocytes or reticuloendothelial macrophages. The binding of iron-laden transferrin to the cell-surface transferrin receptor 1 results in endocytosis and uptake of the metal cargo. Internalized iron is transported to mitochondria for the synthesis of haem or iron–sulfur clusters, which are integral parts of several metalloproteins, and excess iron is stored and detoxified in cytosolic ferritin. Iron metabolism is controlled at different levels and by diverse mechanisms. The present review summarizes basic concepts of iron transport, use and storage and focuses on the IRE (iron-responsive element)/IRP (iron-regulatory protein) system, a well known post-transcriptional regulatory circuit that not only maintains iron homoeostasis in various cell types, but also contributes to systemic iron balance.
Subfields: Genetics, Hematology, Nutrition and Dietetics
View Paper: https://www.semanticscholar.org/paper/cb3471aedede7fb1e2760697ac9993ead65c54ca
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Citations in the corpus
- A Review of Micronutrients and the Immune System–Working in Harmony to Reduce the Risk of Infection (2020, background): “Macrophages are known to contain significant amounts of iron [86], while monocytes and macrophages (and DCs and thymus) contain vitamin D receptors [8].”
- Review on iron and its importance for human health (2014, background): “[19] This process is more efficient than the absorption of inorganic iron and is independent of duodenal pH.”