Models of stochastic gene expression

By Johan Paulsson. 2005

797 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/cb2ecb9caaf524b524eef3553e770322a77204cd

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Citations in the corpus

Noise in protein expression scales with natural protein abundance (2006, background): “Assuming that a single molecule is made or degraded per reaction event, and that the process has a stable stationary state, it has been shown that the noise arising from any such processes can be approximate”
Droplet barcoding for single cell transcriptomics applied to embryonic stem cells (2015, neutral): “Still other expression changes appear to be stochastic in nature (Paulsson, 2005; Swain et al. 2002), and may have important consequences (Losick and Desplan, 2008).”
Quantifying intrinsic and extrinsic noise in gene transcription using the linear noise approximation: An application to single cell data (2013, methodology): “This stochasticity has important consequences for cellular function and it is therefore important to quantify it [Thattai and van Oudenaarden (2001), Paulsson (2004, 2005), Swain, Elowitz and Siggia (2002)].”
Network Inference and Biological Dynamics (2011, background): “This is thought to be the case for the biological systems considered in this paper, but in general the stochasticity due to low copy number will need to be encoded into inference [Paulsson (2005)].”
Principles of maximum entropy and maximum caliber in statistical physics (2013, positive): “…of model making (Gillespie, 1977; van Kampen, 1981; Arkin and Ross, 1995; Qin, Auerbach, and Sachs, 1997, 2000; Rao and Arkin, 2003; Ross, 2003; Paulsson, 2004, 2005; Bratsun et al., 2005; El Samad et al., 2005; Flomenbom, Klafter, and Szabo, 2005; Kaern et al., 2005; Kou et al., 2005;…”
Stochastic switching in biology: from genotype to phenotype (2017, methodology): “24) The system-size expansion has been used extensively to analyze the effects of molecular noise on protein fluctuations in gene expression [83, 202, 237, 240] as well as other cellular processes such as the opening/closing of ion channels [63, 97], see section 8.”