Evolving therapies for myocardial ischemia/reperfusion injury.

By B. Ibáñez, G. Heusch, M. Ovize, F. Van de Werf. Journal of the American College of Cardiology, 2015

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The pathophysiology of acute myocardial infarction and strategies of protection beyond reperfusion: a continual challenge. (2016, background): “Whereas necrosis is considered as an unregulated mode of cell death, more regulated modes of cell death also occur in infarcting myocardium, but their quantitative contribution to final infarct size is not really clear.(17,44,45) Apoptosis is an energy-dependent mode of cell death with typical DNA f”
2017 ESC Guidelines for the management of acute myocardial infarction in patients presenting with ST-segment elevation. (2017, background): “%) in patients with STEMI.163,164 While it is recommended to always treat the IRA, evidence supporting immediate (preventive) revascularization of additional significant coronary stenoses is conflicting.”
Fourth Universal Definition of Myocardial Infarction (2018). (2018, positive): “Timely implementation of reperfusion therapy, when appropriate, reduces ischaemic injury of the myocardium (19,20).”
Fourth universal definition of myocardial infarction (2018). (2019, positive): “Timely implementation of reperfusion therapy, when appropriate, reduces ischaemic injury of the myocardium.(19,20)”
Fourth Universal Definition of Myocardial Infarction (2018). (2018, positive): “Timely implementation of reperfusion therapy, when appropriate, reduces ischaemic injury of the myocardium.(19,20)”