The cell biology of disease: Recent insights into the cellular biology of atherosclerosis
By I. Tabas, G. Garcı́a-Cardeña, G. Owens. 2015
970 citations recorded by the source corpus.
Atherosclerosis occurs in the subendothelial space (intima) of medium-sized arteries at regions of disturbed blood flow and is triggered by an interplay between endothelial dysfunction and subendothelial lipoprotein retention. Over time, this process stimulates a nonresolving inflammatory response that can cause intimal destruction, arterial thrombosis, and end-organ ischemia. Recent advances highlight important cell biological atherogenic processes, including mechanotransduction and inflammatory processes in endothelial cells, origins and contributions of lesional macrophages, and origins and phenotypic switching of lesional smooth muscle cells. These advances illustrate how in-depth mechanistic knowledge of the cellular pathobiology of atherosclerosis can lead to new ideas for therapy.
Subfields: Cell Biology, Epidemiology, Immunology
View Paper: https://www.semanticscholar.org/paper/caf77b04fe848f3edae874da3eb120be2d8ce2f2
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Citations in the corpus
- Cellular Senescence: Aging, Cancer, and Injury. (2019, background): “Many vascular diseases arise because of this sequence of events including myocardial infarction, stroke, unstable angina, and sudden cardiac death (63, 309).”
- Research Progress on the Relationship between Atherosclerosis and Inflammation (2018, background): “In early-stage atherosclerosis, the causes of atherosclerosis are endothelial injury, abnormal lipid metabolism, and hemodynamic damage; and the atherogenic process is considered to be accompanied by flow-mediated inflammatory changes in endothelial cells (ECs) [5].”
- Organotypic vasculature: From descriptive heterogeneity to functional pathophysiology (2017, background): “Yet growing evidence suggests that ECs play a pivotal role in the pathogenesis of atherosclerosis (92, 93).”
- Endothelial Dysfunction in Atherosclerotic Cardiovascular Diseases and Beyond: From Mechanism to Pharmacotherapies (2021, background): “Many studies have demonstrated that abnormal lipid metabolism, inflammatory responses, and hemodynamic alterations are critical players in the occurrence of endothelial dysfunction and atherosclerosis (Tabas et al., 2015).”