Hippocampal damage and exploratory preferences in rats: memory for objects, places, and contexts.

By D. Mumby, S. Gaskin, Melissa J Glenn, T. Schramek, Hugo Lehmann. Learning & memory (Cold Spring Harbor, N.Y.), 2002

751 citations recorded by the source corpus.

Rats have a natural tendency to spend more time exploring novel objects than familiar objects, and this preference can be used as an index of object recognition. Rats also show an exploratory preference for objects in locations where they have not previously encountered objects (an index of place memory) and for familiar objects in contexts different from those in which the objects were originally encountered (an index of context memory). In this experiment, rats with cytotoxic lesions of the hippocampal formation were tested on all three versions of the novelty-preference paradigm, with a 5-min retention interval between the familiarization and test phases. Rats with sham lesions displayed a novelty preference on all three trial types, whereas the rats with hippocampal lesions displayed a novelty preference on Object trials but did not discriminate between the objects on Place trials or Context trials. The findings indicate that hippocampal damage impairs memory for contextual or spatial aspects of an experience, whereas memory for objects that were part of the same experience are left relatively intact.

Subfields: Cellular and Molecular Neuroscience, Cognitive Neuroscience, Neurology

View Paper: https://www.semanticscholar.org/paper/cab27f12427228231f8ff9946c39e7b958283b21

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Citations in the corpus

The medial temporal lobe and recognition memory. (2007, background): “…is moved to a new location or to a new environment during the test phase, selective hippocampal lesions consistently result in deficits even following relatively small lesions of the hippocampus that have no effect on exploration of novel objects (e.g., Eacott & Norman 2004, Mumby et al. 2002).”
Representation of Non-Spatial and Spatial Information in the Lateral Entorhinal Cortex (2011, background): “…of novel objects or misplaced objects in the absence of an overt behavioral task; Frontiers in Behavioral Neuroscience www.frontiersin.org October 2011 | Volume 5 | Article 69 | 10 Mumby et al., 2002), there may be a very sparse representation of individual objects that we did not detect.”
Pericytes control key neurovascular functions and neuronal phenotype in the adult brain and during brain aging (2010, methodology): “The novel object location and recognition tests were performed as previously described (Mumby et al., 2002; Winters and Bussey, 2005).”
The hippocampal indexing theory and episodic memory: Updating the index (2007, background): “Rats with damage to the hippocampus, however, are not sensitive to changing the location of the objects (Mumby et al., 2002; Eacott and Norman, 2004).”
Bacterial infection causes stress-induced memory dysfunction in mice (2010, methodology): “An exploration ratio was calculated (exploration ratio = freq. smell #3/(freq. smell #3 + freq. smell #2B)×100).”
OP 2. Transfer of cognitive training across magnitude dimensions achieved with concurrent brain stimulation of the parietal lobe (2013, background): “The OPR is a spatial memory task, and has been shown to depend critically on intact hippocampal function (Bussey et al., 2000; Mumby et al., 2002).”
When Is the Hippocampus Involved in Recognition Memory? (2011, result): “While a number of studies show that hippocampal or fornix lesions produce no effect in object recognition (Bussey et al., 2000; Mumby et al., 2002; Winters et al., 2004; Forwood et al., 2005; Good et al., 2007; Langston and Wood, 2010), other studies report significant impairments (Clark et al.,…”