Diabetic Cardiovascular Autonomic Neuropathy

By A. Vinik, Dan Ziegler. Circulation, 2007

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Diabetic Neuropathies: Update on Definitions, Diagnostic Criteria, Estimation of Severity, and Treatments (2010, background): “Some pathogenetic mechanisms may link CAN to cardiovascular dysfunction and diabetic complications (34).”
Cardiovascular autonomic neuropathy in diabetes: clinical impact, assessment, diagnosis, and management (2011, background): “There is no statistical evidence of a striking superiority in diagnostic characteristics of a cardiovascular heart rate test over the others [18].”
Update on the treatment of type 2 diabetes mellitus. (2016, background): “…with autonomic neuropathy and those who do not have it [54] , however it may represent a prescription limitation because it may favour silent ischemia, doubling mortality, impairing exercise tolerance and decreasing the maximum heart rate and thus a prior cardiovascular study is recommended [55] .”
Diabetic Neuropathy (2010, neutral): “Damage to small thinly and unmyelinated nerves or autonomic fibers can be measured by quantitative sensory testing, autonomic testing and laser-Doppler flowmetry (3-6).”