Large-scale genetic perturbations reveal regulatory networks and an abundance of gene-specific repressors.
By Patrick Kemmeren, K. Sameith, Loes A L van de Pasch, J. Benschop, T. Lenstra, T. Margaritis, E. O’Duibhir, Eva Apweiler, Sake van Wageningen, Cheuk W Ko and 16 more. 2014
313 citations recorded by the source corpus.
Subfields: Molecular Biology
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In Molecular Biology
- Bernhard Schölkopf
- Nicolai Meinshausen
- Jan Peters
- Aviv Regev
- Eric S. Lander
- Nir Friedman
- Job Dekker
- Jonathan S. Weissman
Citations in the corpus
- Causal inference by using invariant prediction: identification and confidence intervals (2015, methodology): “We applied our method to a yeast (Saccharomyces cerevisiae) data set (Kemmeren et al., 2014).”
- Causal Transfer in Machine Learning (2015, methodology): “We apply our method to gene perturbation data provided by Kemmeren et al. [2014].”
- Identifying Best Interventions through Online Importance Sampling (2017, background): “There are two important questions commonly studied with causal graphs: (i) How to learn a directed causal graph that encodes the pattern of interaction among components in a system (casual structure learning)? [28] , and (ii) Using previously acquired (partial) knowledge about the causal graph struc”
- Mapping nucleosome resolution chromosome folding in yeast by Micro-C (2015, background): “Comparison of gene compaction with data from 700 yeast deletion mutants (Kemmeren et al., 2014) revealed that unusually compact genes were derepressed in mutants lacking various histone deacetylases (including Cyc8/ Tup1 and Sum1/Hst1), histone turnover machinery (such as Rtt109 and Asf1), or Mediat”
- Invariant Models for Causal Transfer Learning (2015, methodology): “We apply our method to gene perturbation data provided by Kemmeren et al. (2014).”
- Perturb-Seq: Dissecting Molecular Circuits with Scalable Single-Cell RNA Profiling of Pooled Genetic Screens. (2016, background): “1862 Cell 167, 1853–1866, December 15, 2016 of targets similarly affected across sets of perturbations, consistent with modular gene regulation (Heimberg et al., 2016; Kemmeren et al., 2014).”