Role of the vascular endothelial growth factor pathway in tumor growth and angiogenesis.

By D. Hicklin, L. Ellis. Journal of Clinical Oncology, 2005

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Autocrine VEGF signaling is required for vascular homeostasis. (2007, neutral): “In the adult, ample experimental evidence has unequivocally shown that VEGF is required for pathological growth of vessels in many conditions including inflammation, retinopathies, and arthritis (Dvorak, 2006; Hicklin and Ellis, 2005; Folkman, 2007).”
VEGF-targeted therapy: mechanisms of anti-tumour activity (2008, background): “VEGF biology The mammalian VEGF family consists of five glycoproteins referred to as VEGFA , VEGFB , VEGFC , VEGFD (also known as FIGF ) and placenta growth factor (PlGF, also known as PGF”
Metabolic reprogramming: the emerging concept and associated therapeutic strategies (2015, background): “However, this is not the case in proliferating cancer cells with aberrant angiogenesis [29].”
Molecular basis for sunitinib efficacy and future clinical development (2007, background): “VEGF is one of the key pro-angiogenic factors that initiates tumour angiogenesi”
Revisiting the hallmarks of cancer. (2017, positive): “Controlled by HIF activity, and also directly by growth signaling, VEGF is overexpressed in a multitude of malignancies [84] and its activated signaling leads to EC proliferation, survival, migration and differentiation, and mediation of vascular permeability [82, 85].”