International Clinical Practice Guidelines for Sarcopenia (ICFSR): Screening, Diagnosis and Management

By E. Dent, J. Morley, A. Cruz-Jentoft, H. Arai, Stephen B. Kritchevsky, Jack M. Guralnik, J. Bauer, Marco Pahor, Brian C. Clark, M. Cesari and 28 more. The Journal of Nutrition, Health & Aging, 2018

912 citations recorded by the source corpus.

ObjectivesSarcopenia, defined as an age-associated loss of skeletal muscle function and muscle mass, occurs in approximately 6 - 22 % of older adults. This paper presents evidence-based clinical practice guidelines for screening, diagnosis and management of sarcopenia from the task force of the International Conference on Sarcopenia and Frailty Research (ICSFR).MethodsTo develop the guidelines, we drew upon the best available evidence from two systematic reviews paired with consensus statements by international working groups on sarcopenia. Eight topics were selected for the recommendations: (i) defining sarcopenia; (ii) screening and diagnosis; (iii) physical activity prescription; (iv) protein supplementation; (v) vitamin D supplementation; (vi) anabolic hormone prescription; (vii) medications under development; and (viii) research. The ICSFR task force evaluated the evidence behind each topic including the quality of evidence, the benefitharm balance of treatment, patient preferences/values, and cost-effectiveness. Recommendations were graded as either strong or conditional (weak) as per the GRADE (Grading of Recommendations Assessment, Development and Evaluation) approach. Consensus was achieved via one face-to-face workshop and a modified Delphi process.RecommendationsWe make a conditional recommendation for the use of an internationally accepted measurement tool for the diagnosis of sarcopenia including the EWGSOP and FNIH definitions, and advocate for rapid screening using gait speed or the SARC-F. To treat sarcopenia, we strongly recommend the prescription of resistance-based physical activity, and conditionally recommend protein supplementation/a protein-rich diet. No recommendation is given for Vitamin D supplementation or for anabolic hormone prescription. There is a lack of robust evidence to assess the strength of other treatment options.

Subfields: Cell Biology, Geriatrics and Gerontology, Physiology

View Paper: https://www.semanticscholar.org/paper/c99967d262ecd14f49c534bf7ddf3a29582a769e

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The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Geriatrics and Gerontology

1. Luigi Ferrucci
2. J. Morley
3. L. Fried
4. Emiel Hoogendijk
5. E. Dent
6. Arnold Mitnitski
7. Kenneth Rockwood

In Physiology

1. Luigi Ferrucci
2. J. Morley
3. L. Fried
4. Arnold Mitnitski
5. Kenneth Rockwood
6. M. F. Holick

Citations in the corpus

• Physical Frailty: ICFSR International Clinical Practice Guidelines for Identification and Management (2019, background): “Physical frailty is also related to sarcopenia [low muscle strength and/or muscle quantity of quality] (45-48), with clinical management of the two conditions overlapping somewhat (33, 49).”
• International Exercise Recommendations in Older Adults (ICFSR): Expert Consensus Guidelines (2021, neutral): “Both frailty and sarcopenia are associated with many adverse outcomes including falls, disability, cognitive decline, and mortality (29, 37, 217).”
• Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD): A State-of-the-Art Review (2023, background): “111 Increased physical activity and healthy diet have been associated with lower risk of sarcopenia and MASLD and could even reduce the risk of significant liver fibrosis.”