A Perspective on Enzyme Catalysis

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Assessment of the protein-structure refinement category in CASP8 (2009, background): “26–28 In this respect, nuclear magnetic resonance (NMR) spectroscopy can provide information for both structure and dynamics of proteins in a physiologically relevant environment.”
Biotechnological relevance of the lipase A from Candida antarctica (2021, neutral): “adequate in their physiological function [12].”
Intrinsic dynamics of an enzyme underlies catalysis (2005, background): “It also implies that the chemical shifts between the two states (Dq),and hence their structural differences, are identical for wild-type CypA and all CypA mutants (scheme (3)); Supplementary Table S2).”
Outlook for cellulase improvement: screening and selection strategies. (2006, background): “For example, a significant increase (10(6)-fold) in the specificity constant (kcat/KM) of aspartate aminotransferase favoring valine requires 17 amino-acid changes, only one of which occurs within the active-site (Benkovic and Mames-Schiffer, 2003).”