Faculty Opinions recommendation of CLV3 is localized to the extracellular space, where it activates the Arabidopsis CLAVATA stem cell signaling pathway.

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The Vegetative Vacuole Proteome of Arabidopsis thaliana Reveals Predicted and Unexpected Proteinsw⃞ (2004, background): “However, the CTPP pathway was proven to be fully functional in Arabidopsis plants, as recombinant CTPP proteins from other plants species were properly targeted to the vacuole via dense vesicles (Ahmed et al., 2000; Rojo et al., 2002).”