Tryptophan Hydroxylase-2 Controls Brain Serotonin Synthesis

By Xiaodong Zhang, J. Beaulieu, T. Sotnikova, R. Gainetdinov, M. Caron. Science, 2004

693 citations recorded by the source corpus.

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

Model organisms: The ascent of mouse: advances in modelling human depression and anxiety (2005, neutral): “For example, the BALB/cJ and DBA/2J strains carry a mutant allele for the brain-specific serotonin-synthesizing enzyme tryptophan hydroxylase 2 ( Tph2 ), which results in a considerably lower brain serotonin concentration in these strains compared with the C57BL/6J and 129X1/SvJ strains that do not ”
The neurobiology of aggression and violence (2015, methodology): “Tryptophan hydroxylase-2 (tph2) was recently found to be the brain-specific, rate-limiting enzyme mediating 5-HT synthesis.(98) The mouse tph2 single nucleotide polymorphism (SNP) C1437G has been associated with differential rates of 5-HT synthesis, and was used as a model to examine aggressive beha”
Treatment-resistant depression: therapeutic trends, challenges, and future directions (2012, positive): “42 Also, based on an experimental animal study, 43 researchers reported discovering a mutant gene on chromosome 12 that codes for tryptophan hydroxylase-2.”