Clades of Adeno-Associated Viruses Are Widely Disseminated in Human Tissues

By G. Gao, L. Vandenberghe, M. R. Delgado Alvira, You Lu, R. Calcedo, Xiangyang Zhou, James M. Wilson. Journal of Virology, 2004

1,049 citations recorded by the source corpus.

Subfields: Animal Science and Zoology, Genetics, Infectious Diseases

View Paper: https://www.semanticscholar.org/paper/c92e4de00be8cd7589fccbedf7d8b8fd547504ca

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Edward C. Holmes

Citations in the corpus

Intravascular AAV9 preferentially targets neonatal-neurons and adult-astrocytes in CNS (2008, background): “Neutralizing antibodies created against AAV serotypes 1–8 showed little to no cross-reactivity with AAV9, indicating that AAV9 is of a different AAV clad”
Robust systemic transduction with AAV9 vectors in mice: efficient global cardiac gene transfer superior to that of AAV8. (2006, methodology): “, we selected rAAV9 as the most likely candidate for a comparative study with rAAV8 [1].”
Prevalence of Serum IgG and Neutralizing Factors Against Adeno-Associated Virus (AAV) Types 1, 2, 5, 6, 8, and 9 in the Healthy Population: Implications for Gene Therapy Using AAV Vectors (2010, neutral): “1 for AAV2 (Li et al. , 1997), pLT-RC02 for AAV1 (Riviere et al. , 2006), pLT-RC03 for AAV5 (Riviere et al. , 2006), pLTRCO6 for AAV6 (Riviere et al. , 2006), p5e18-VD2-8 for AAV8 (Gao et al. , 2002), and pAAV-2 = 9 for AAV9 (Gao et al. , 2004); and the relevant pAAV2 vector plasmid.”
Adeno-associated virus serotype 8 efficiently delivers genes to muscle and heart (2005, background): “Recently, a number of new AAV serotype vectors, including AAV7 and AAV8, have become availabl”
Adeno-associated virus as a delivery vector for gene therapy of human diseases (2024, background): “12,13,25 Human seroprevalence studies have revealed that a signi ﬁ cant proportion of populations possess neutralizing antibodies (NAbs) against multiple AAV serotypes.”
Short Communication Comparative analysis reveals frequent recombination in the parvoviruses (2007, background): “Likewise, multiple strains of AAV infect humans and more than one genotype can be found in an individual (Gao et al., 2004).”
Adeno-associated virus serotypes: vector toolkit for human gene therapy. (2006, background): “iver AAV8, AAV9 [16,17,68,71] keletal muscle AAV1, AAV7, AAV6, AAV8, AAV9 [16,17,23,60,63]”