Dexamethasone for the Prevention of Postoperative Nausea and Vomiting: A Quantitative Systematic Review

By I. Henzi, B. Walder, M. Tramèr. Anesthesia and Analgesia, 2000

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Society for Ambulatory Anesthesia Guidelines for the Management of Postoperative Nausea and Vomiting (2007, background): “The 5-HT3 antagonists can also be effectively combined with dexamethasone (55).”
Consensus Guidelines for Managing Postoperative Nausea and Vomiting (2003, background): “Side effects with long-term administration of corticosteroids can include wound infection and adrenal suppression, among others, but adverse events have not been noted after a single bolus dose of dexamethasone (44).”
Multimodal strategies to improve surgical outcome. (2002, background): “A single dose of dexamethasone given preoperatively reduces nausea and vomiting in minor to moderate sized operations [81].”
Consensus Guidelines for the Management of Postoperative Nausea and Vomiting (2014, background): “…specific therapeutic combinations showed the combination of a 5-HT 3 receptor antagonist with either dexamethasone or droperi-dol was more effective than monotherapy with any of the drugs 255,188,189,256 Similarly, droperidol combined with dexamethasone was more effective than either drug alone.”