Sphingolipid metabolites in inflammatory disease

By Michael Maceyka, Sarah Spiegel. Nature, 2014

1,180 citations recorded by the source corpus.

Sphingolipids are ubiquitous building blocks of eukaryotic cell membranes. Progress in our understanding of sphingolipid metabolism, state-of-the-art sphingolipidomic approaches and animal models have generated a large body of evidence demonstrating that sphingolipid metabolites, particularly ceramide and sphingosine-1-phosphate, are signalling molecules that regulate a diverse range of cellular processes that are important in immunity, inflammation and inflammatory disorders. Recent insights into the molecular mechanisms of action of sphingolipid metabolites and new perspectives on their roles in regulating chronic inflammation have been reported. The knowledge gained in this emerging field will aid in the development of new therapeutic options for inflammatory disorders.

Subfields: Molecular Biology

View Paper: https://www.semanticscholar.org/paper/c86bc772676570868957cb1766e62e7015cd2301

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In Molecular Biology

1. H. D. Alexander
2. I.Maeve Rea
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4. David S. Gibson
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Citations in the corpus

• Age and Age-Related Diseases: Role of Inflammation Triggers and Cytokines (2018, background): “There is interest in the role of sphingolipid metabolites, such as ceramide and sphingosine-1-phosphate, which regulate a diverse range of cellular processes that are important in immunity, inflammation, and inflammatory diseases (367).”