Tyrosinase inhibitors from natural and synthetic sources: structure, inhibition mechanism and perspective for the future

By Y. Kim, H. Uyama. Cellular and Molecular Life Sciences (CMLS), 2005

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Liquorice (Glycyrrhiza glabra): A phytochemical and pharmacological review (2018, background): “The presence of an α-keto group in flavonoids is responsible for this activity (Y. J. Kim & Uyama, 2005; Parvez et al., 2007) .”
Hypopigmenting agents: an updated review on biological, chemical and clinical aspects. (2006, background): “They are classified into six major groups, flavanols, flavones, flavonols, flavanones, isoflavones and anthocyanidins, which differ in the conjugation of rings and the position of hydroxyl, methoxy and glycosidic groups (Kim and Uyama, 2005).”
Crystal structure of Agaricus bisporus mushroom tyrosinase: identity of the tetramer subunits and interaction with tropolone. (2011, neutral): “57,58 The Ab TYR crystal structure may take this search from the ad-hoc nature that it has had until now to a more directed and targeted e ﬀ ort for this commercially important enzyme.”
Signaling Pathways in Melanogenesis (2016, background): “A number of tyrosinase inhibitors from both natural and synthetic sources have become available to date (reviewed in [43]), although further research is required to make these inhibitors available for patients suffering from undesired effects of tyrosinase.”
An Updated Review of Tyrosinase Inhibitors (2009, background): “Some tyrosinase inhibitors have been discovered and reviewed before [7-9]; this article surveys tyrosinase inhibitors newly discovered from natural and synthetic sources.”