Excess placental soluble fms-like tyrosine kinase 1 (sFlt1) may contribute to endothelial dysfunction, hypertension, and proteinuria in preeclampsia.

By S. Maynard, J. Min, J. Merchan, K. Lim, Jianyi Li, S. Mondal, T. Libermann, James P. Morgan, Frank W. Sellke, Isaac E. Stillman and 3 more. Journal of Clinical Investigation, 2003

2,657 citations recorded by the source corpus.

Subfields: Molecular Biology, Obstetrics and Gynecology, Pediatrics, Perinatology and Child Health

View Paper: https://www.semanticscholar.org/paper/c84923024e2a6504b97de159df169a0e8fdb6f65

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Citations in the corpus

• Placental stress and pre-eclampsia: a revised view. (2009, background): “When present in excess, as in pre-eclampsia, it binds to, and inactivates, VEGF, a key survival factor for endothelium [34], and thereby induces systemic endothelial dysfunction.”