γH2AX and cancer

By W. Bonner, C. Redon, J. Dickey, A. Nakamura, O. Sedelnikova, S. Solier, Yves Pommier. Nature Reviews. Cancer, 2008

1,308 citations recorded by the source corpus.

Histone H2AX phosphorylation on a serine four residues from the carboxyl terminus (producing γH2AX) is a sensitive marker for DNA double-strand breaks (DSBs). DSBs may lead to cancer but, paradoxically, are also used to kill cancer cells. Using γH2AX detection to determine the extent of DSB induction may help to detect precancerous cells, to stage cancers, to monitor the effectiveness of cancer therapies and to develop novel anticancer drugs.

Subfields: Molecular Biology, Oncology

View Paper: https://www.semanticscholar.org/paper/c81808cdc66d426920916ad166a2ce5e7baa80ae

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In Molecular Biology

1. S. Polo
2. Stephen P. Jackson
3. Yosef Shiloh
4. J. Bartek

In Oncology

1. S. Polo
2. Stephen P. Jackson
3. Yosef Shiloh

Citations in the corpus

• Dynamics of DNA damage response proteins at DNA breaks: a focus on protein modifications. (2011, background): “…of this is illustrated by the H2AX C-terminal sequence and the tandem BRCT domains that recognize gH2AX, both of which are conserved from yeasts to humans with only a very few known exceptions (Lee et al. 2005; Stucki et al. 2005; Hammet et al. 2007; Bonner et al. 2008; Kilkenny et al. 2008).”