NADPH oxidases: an overview from structure to innate immunity-associated pathologies

By Arvind Panday, M. Sahoo, Diana Osorio, S. Batra. Cellular & Molecular Immunology, 2014

839 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/c803614b8bd8c5b55bf000c8ca63a19097e03f06

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Citations in the corpus

Oxidative stress and reactive oxygen species in endothelial dysfunction associated with cardiovascular and metabolic diseases. (2018, neutral): “The NADPH oxidases (NOX), a family of seven membrane-bound enzyme complexes, catalyze the reduction of molecular oxygen to O2 ● by using NADPH as electron donor, thus producing ROS as their only function [1-3, 7, 37, 38], and this reflects their specific role in inducing a burst of ROS”
ROS Generation and Antioxidant Defense Systems in Normal and Malignant Cells (2019, background): “NOX could be activated by various infectious agents resulting in increased ROS production which promotes the death of the infected cells as well as an inflammatory response [162].”
Oxidative Stress in Human Pathology and Aging: Molecular Mechanisms and Perspectives (2022, background): “H2O2 diffuses through the cell membrane through aquaporin water channels (AQP) transducing the redox signal from the place where it is produced to a target site [52].”
Neutrophils to the ROScue: Mechanisms of NADPH Oxidase Activation and Bacterial Resistance (2017, background): “…| www.frontiersin.org 3 August 2017 | Volume 7 | Article 373 (Figure 2) (Cross and Segal, 2004; Groemping and Rittinger, 2005; Nunes et al., 2013; Panday et al., 2015; El-Benna et al., 2016). p22phox acts as a docking site for the regulatory trimeric complex via its interaction with p47phox…”
Several lines of antioxidant defense against oxidative stress: antioxidant enzymes, nanomaterials with multiple enzyme-mimicking activities, and low-molecular-weight antioxidants (2024, background): “NADPH (nicotinamide adenine dinucleotide phosphate oxidase) is a membrane-bound enzyme complex that occurs in white blood and vascular cells (Panday et al. 2015).”