The Catalogue of Somatic Mutations in Cancer (COSMIC)

By S. Forbes, G. Bhamra, S. Bamford, E. Dawson, C. Kok, Jody Clements, A. Menzies, J. Teague, P. Futreal, Michael R. Stratton. Current Protocols in Human Genetics, 2008

981 citations recorded by the source corpus.

COSMIC is currently the most comprehensive global resource for information on somatic mutations in human cancer, combining curation of the scientific literature with tumor resequencing data from the Cancer Genome Project at the Sanger Institute, U.K. Almost 4800 genes and 250000 tumors have been examined, resulting in over 50000 mutations available for investigation. This information can be accessed in a number of ways, the most convenient being the Web‐based system which allows detailed data mining, presenting the results in easily interpretable formats. This unit describes the graphical system in detail, elaborating an example walkthrough and the many ways that the resulting information can be thoroughly investigated by combining data, respecializing the query, or viewing the results in different ways. Alternate protocols overview the available precompiled data files available for download. Curr. Protoc. Hum. Genet. 57:10.11.1‐10.11.26. © 2008 by John Wiley & Sons, Inc.

Subfields: Cancer Research, Genetics, Pathology and Forensic Medicine

View Paper: https://www.semanticscholar.org/paper/c7fcf8c80352b2ea561b2004f14e28287977eab6

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Citations in the corpus

An overview of the c-MET signaling pathway (2011, background): “Mutations have also been identified in the c-CBL binding site of the juxtamembrane domain and in the HGF-binding region of the Sema domain [Forbes et al. 2008].”
Circos: an information aesthetic for comparative genomics. (2009, background): “…genomic data (Campbell et al. 2008; Constantine 2007; Hampton et al. 2009; Jaillon et al. 2007; Meyer et al. 2009), in online genomics resources (Forbes et al. 2008), mainstream periodicals and newspapers (Constantine 2007; Duncan 2007; Ostrander 2007; Zimmer 2008) as well as to visualize data…”
DISEASES: Text mining and data integration of disease–gene associations (2014, methodology): “To integrate cancer mutation data from COSMIC [29], we manually created mappings between terms listed in the fields “Site primary” and “Histology” and Disease Ontology concepts classified under “organ system cancer” and “cell type cancer”, respectively.”
COSMIC (the Catalogue of Somatic Mutations in Cancer): a resource to investigate acquired mutations in human cancer (2009, neutral): “A much lengthier discussion of the data in COSMIC and its navigation is available as a Protocol document (6).”
COSMIC: mining complete cancer genomes in the Catalogue of Somatic Mutations in Cancer (2010, methodology): “As previously described (1,2), COSMIC combines cancer mutation data manually curated from the scientific literature, with the output from the Cancer Genome Project (CGP) at the Sanger Institute UK.”