Functions of DNA methylation: islands, start sites, gene bodies and beyond

By Peter A. Jones. Nature reviews genetics, 2012

5,607 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/c7e6d7b8733bf66072db0c20fdac5dfdf95eee23

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In Molecular Biology

Citations in the corpus

Brain Plasticity and Human Evolution (2017, neutral): “DNA methylation is one of the best known epigenetic markers, and it can impact gene expression through several different mechanisms ( Jones 2012).”
DeepCpG: accurate prediction of single-cell DNA methylation states using deep learning (2016, background): “DNA methylation is one of the most extensively studied epigenetic marks and is known to be implicated in a wide range of biological processes, including chromosome instability, X-chromosome inactivation, cell differentiation, cancer progression and gene regulation [1 – 4].”
Analysing and interpreting DNA methylation data (2012, background): “This range coincides with typical sizes of gene‑ regulatory regions, and it is widely believed that DMRs can control cell‑type‑specific transcriptional repression of an associated gene 1,3,88 .”
Histone Marks in the 'Driver's Seat': Functional Roles in Steering the Transcription Cycle. (2017, background): “While DNA methylation in promoter regions is associated with transcription repression, gene body DNA methylation is associated with active transcription [69].”
edgeR v4: powerful differential analysis of sequencing data with expanded functionality and improved support for small counts and larger datasets (2024, neutral): “Given the fact that unmethylated CpGs are often enriched in gene promoters [, 13 , 68–70 ], a gene oriented differential methylation analysis can be conducted by aggregating the methylated and un-methylated CpG counts in gene promoter regions [ 13 ].”
Transcriptional Regulation and its Misregulation in Disease (2013, neutral): “Repressed genes are embedded in chromatin with modifications that are characteristic of specific repression mechanisms (Beisel and Paro, 2011; Cedar and Bergman, 2012; Jones, 2012; Moazed, 2009; Reyes-Turcu and Grewal, 2012).”
A Six Months Exercise Intervention Influences the Genome-wide DNA Methylation Pattern in Human Adipose Tissue (2013, neutral): “It has long been debated if increased DNA methylation precedes gene silencing, or if it is rather a consequence of altered gene activity [40].”
Epigenetic plasticity and the hallmarks of cancer (2017, background): “DNA methylation plays diverse roles in repetitive element silencing, in parent-of-origin allelic imprinting, and in transcriptional elongation and RNA splicing (39).”
Targeting epigenetic regulators for cancer therapy: mechanisms and advances in clinical trials (2019, background): “This process often occurs in CpG-poor areas and causes a base transition from C to T.(34) The hypermethylation of specific CpG islands in cancer tissues is informative of mutations when the gene in normal tissues is unmethylated.”
Epigenetic Determinants of Cancer. (2016, methodology): “S.B. Baylin and P.A. Jones 2 Cite this article as Cold Spring Harb Perspect Biol 2016;8:a019505”