Complement and its role in innate and adaptive immune responses

By J. Dunkelberger, W. Song. Cell Research, 2010

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Complement System Part II: Role in Immunity (2015, background): “This may be explained by the overactivation of complement leading to strong local anaphylatoxin production (153).”
Inflammation and its role in age-related macular degeneration (2016, background): “Components C5a and C3a are called anaphylatoxins due to their ability to promote inflammation [92].”
Biodistribution and Delivery Efficiency of Unmodified Tumor-Derived Exosomes (2014, background): “C5 is required for hemolytic complement activity [51], acts as a chemoattractant for cells of the RES [72], and promotes phagocytosis [73–75].”
The inflammatory response to extracorporeal membrane oxygenation (ECMO): a review of the pathophysiology (2016, neutral): “of pro-inflammatory anaphylatoxins [75].”
The Complement System (2010, background): “…recently, it is becoming increasingly evident that complement also plays an important role in adaptive immunity involving T and B cells that help in elimination of pathogens (Dunkelberger and Song 2010; Molina et al. 1996) and in maintaining immunologic memory preventing pathogenic re-invasion.”