Improvement in Outcomes of Clinical Islet Transplantation: 1999–2010

By F. Barton, M. Rickels, R. Alejandro, B. Hering, S. Wease, B. Naziruddin, J. Oberholzer, J. Odorico, M. Garfinkel, M. Levy and 26 more. Diabetes Care, 2012

709 citations recorded by the source corpus.

OBJECTIVE To describe trends of primary efficacy and safety outcomes of islet transplantation in type 1 diabetes recipients with severe hypoglycemia from the Collaborative Islet Transplant Registry (CITR) from 1999 to 2010. RESEARCH DESIGN AND METHODS A total of 677 islet transplant-alone or islet-after-kidney recipients with type 1 diabetes in the CITR were analyzed for five primary efficacy outcomes and overall safety to identify any differences by early (1999–2002), mid (2003–2006), or recent (2007–2010) transplant era based on annual follow-up to 5 years. RESULTS Insulin independence at 3 years after transplant improved from 27% in the early era (1999–2002, n = 214) to 37% in the mid (2003–2006, n = 255) and to 44% in the most recent era (2007–2010, n = 208; P = 0.006 for years-by-era; P = 0.01 for era alone). C-peptide ≥0.3 ng/mL, indicative of islet graft function, was retained longer in the most recent era (P < 0.001). Reduction of HbA1c and resolution of severe hypoglycemia exhibited enduring long-term effects. Fasting blood glucose stabilization also showed improvements in the most recent era. There were also modest reductions in the occurrence of adverse events. The islet reinfusion rate was lower: 48% by 1 year in 2007–2010 vs. 60–65% in 1999–2006 (P < 0.01). Recipients that ever achieved insulin-independence experienced longer duration of islet graft function (P < 0.001). CONCLUSIONS The CITR shows improvement in primary efficacy and safety outcomes of islet transplantation in recipients who received transplants in 2007–2010 compared with those in 1999–2006, with fewer islet infusions and adverse events per recipient.

Subfields: Endocrinology, Diabetes and Metabolism, Genetics, Surgery

View Paper: https://www.semanticscholar.org/paper/c756342b69aff71896dca3bafebde86f9630fd67

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In Endocrinology, Diabetes and Metabolism

  1. Eric Renard
  2. J. Hans DeVries
  3. I. Hirsch
  4. M. S. Kirkman
  5. V. Basevi

In Genetics

  1. J. Hans DeVries
  2. I. Hirsch
  3. M. S. Kirkman

In Surgery

  1. Eric Renard
  2. J. Hans DeVries
  3. I. Hirsch
  4. M. S. Kirkman

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