Exosome-Mediated Metastasis: Communication from a Distance.

By I. Wortzel, S. Dror, C. Kenific, D. Lyden. Developmental Cell, 2019

1,101 citations recorded by the source corpus.

Metastasis, a critical phase of tumor progression, remains a primary challenge in treating cancer and a major cause of cancer mortality. Cell-cell communication via extracellular vesicles (exosomes and microvesicles) between primary tumor cells and the microenvironment of distant organs is crucial for pre-metastatic niche (PMN) formation and metastasis. Here, we review work on the contribution of exosome cargo to cancer progression, the role of exosomes in PMN establishment, and the function of exosomes in organotropic metastasis. We also describe the clinical utility of exosomes.

Subfields: Cancer Research, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/c7504fa8bc52aabdbe6d52c20128ab5e96107e30

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In Cancer Research

1. C. Alix‐Panabières
2. K. Pantel

In Molecular Biology

1. C. Alix‐Panabières
2. K. Pantel

Citations in the corpus

• Liquid Biopsy: From Discovery to Clinical Application. (2021, background): “Nucleic acids and proteins transported in exosomes from primary lesions to distant sites can be taken up by recipient cells and change tumor biology (150, 151).”