Demyelination increases radial diffusivity in corpus callosum of mouse brain

By Sheng-Kwei Song, Jun Yoshino, T. Q. Le, Shiow J. Lin, Shu-wei Sun, A. Cross, R. Armstrong. NeuroImage, 2005

1,710 citations recorded by the source corpus.

Subfields: Pathology and Forensic Medicine, Psychiatry and Mental health, Radiology, Nuclear Medicine and Imaging

View Paper: https://www.semanticscholar.org/paper/c6d9f33d2771f9749d04e0bfc10967b28ae01dc6

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In Pathology and Forensic Medicine

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Citations in the corpus

Brain maturation in adolescence and young adulthood: regional age-related changes in cortical thickness and white matter volume and microstructure. (2010, background): “Although many factors most likely influence the different diffusion parameters, studies on mice by Song et al. (2002, 2003, 2005) indicate that degree of myelination is one important factor for DR, but not DA.”
Motor control and aging: links to age-related brain structural, functional, and biochemical effects. (2010, positive): “…tensor imaging is the ability to differentiate between microstructural deterioration of axonal integrity (assessed by longitudinal or axial diffusivity) as opposed to myelin integrity (assessed by radial or transverse diffusivity; Gulani et al., 2001; Song et al., 2003, 2005; Sun et al., 2006).”
Diffusion Tensor Imaging and Beyond (2011, positive): “Past studies have shown that myelin loss is correlated with an increase in perpendicular diffusivity, whereas axonal loss is related more to a decrease in the parallel diffusivity (87,88).”
Longitudinal Development of Human Brain Wiring Continues from Childhood into Adulthood (2011, background): “Animal studies show that is related to myelination and axonal packing (Beaulieu, 2002; Song et al., 2005), whereas // can vary with fiber diameter and axon coherence (Takahashi et al., 2000).”
Diffusion tensor imaging of white matter tract evolution over the lifespan (2012, background): “…diffusion may indicate increased myelination, more densely packed axons, or some combination of the two (Beaulieu, 2002; Jones et al., 1999; Song et al., 2003, 2005), whereas parallel diffusion tends to reflect fiber diameter or organization (Takahashi et al., 2000); brain water content…”
Radial Diffusivity Predicts Demyelination in ex-vivo Multiple Sclerosis Spinal Cords (2011, positive): “This finding corroborates previously published histopathology correlation studies in animal models (Song et al., 2002, 2003, 2005).”
Life-span changes of the human brain white matter: diffusion tensor imaging (DTI) and volumetry. (2010, background): “Nevertheless, the magnitude of the radial eigenvalue has been shown to be sensitive to de-and dysmyelination in mice (Song et al. 2002, 2005), suggesting some myelin specificity of RD.”
Assessing the effects of age on long white matter tracts using diffusion tensor tractography (2009, background): “Taken together with previous neurobiological studies (Song et al., 2005; Sun et al., 2007; Trip et al., 2006) and complementary findings in callosectomy patients (Concha et al., 2006) and MS (Schmierer et al., 2004) suggesting dissociations between RD/myelination and AD/axonal integrity, this…”
Microstructural maturation of the human brain from childhood to adulthood (2008, positive): “Remyelination in the mouse brain is characterized by decreases of perpendicular diffusivity without corresponding changes of parallel diffusivity (Song et al., 2005), suggesting that increasing myelination with age may be the cause of the drop of perpendicular diffusivity in our population.”
Age-related differences in white matter microstructure: Region-specific patterns of diffusivity (2010, background): “In these voxels, RD and AD cannot serve as markers of myelin and axon integrity, respectively (Song et al., 2002, 2003, 2005), and the patterns should be interpreted with caution.”
The Development of Brain White Matter Microstructure (2018, background): “Axial and radial diffusivity from DTI provide increased specificity to axonal integrity, and myelin and fibre density (Song et al., 2003, 2002, 2005), respectively, than FA or MD. DTI studies of neurodevelopment most commonly find that age-related FA increases and/or MD decreases are accompanied by…”