Human commensals producing a novel antibiotic impair pathogen colonization

By Alexander Zipperer, Martin C. Konnerth, C. Laux, Anne Berscheid, D. Janek, Christopher Weidenmaier, Marc Burian, Nadine A. Schilling, Christoph J Slavetinsky, M. Marschal and 7 more. Nature, 2016

801 citations recorded by the source corpus.

Subfields: Food Science, Infectious Diseases, Microbiology

View Paper: https://www.semanticscholar.org/paper/c6cda646eb22e0ae7fc70b6f29a6ff29430ad84b

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In Infectious Diseases

1. M. Huemer
2. S. Brugger
3. Annelies S. Zinkernagel
4. Srikanth Mairpady Shambat

Citations in the corpus

• The microbiota of the respiratory tract: gatekeeper to respiratory health (2017, background): “Furthermore, interactions between species in the Staphylococcus genus might help to prevent S. aureus from overgrowing as well; for example, its colonization is hindered by serine protease activity in S. epidermidis 71 and by the production of lugdunin by Staphylococcus lugdunensis, which is a natur”
• Antibiotic resistance and persistence—Implications for human health and treatment perspectives (2020, positive): “The macrocyclic thiazolidine peptide antibiotic lugdunin is active against a wide range of Gram-positive pathogens including MRSA and VRE with a high barrier to resistance by mutation (Zipperer et al , 2016) (Fig 5A).”