Mesenchymal Stromal Cells Modulate Macrophages in Clinically Relevant Lung Injury Models by Extracellular Vesicle Mitochondrial Transfer

By T. Morrison, M. Jackson, E. K. Cunningham, A. Kissenpfennig, D. McAuley, C. O’Kane, A. Krasnodembskaya. American Journal of Respiratory and Critical Care Medicine, 2017

643 citations recorded by the source corpus.

Subfields: Genetics, Immunology, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/c6a517019356cee878fea6476d9d4b6325451a6a

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1. C. Shao
2. Jiankai Fang
3. Jihong Wang
4. Yuyi Han
5. Yufang Shi
6. De-chen Liu
7. Hao Li
8. Junjie Gao

Citations in the corpus

• The secretion profile of mesenchymal stem cells and potential applications in treating human diseases (2022, background): “The mitochondria of donor MSCs, carried by EVs, can be transferred to neighboring macrophages to enhance oxidative phosphorylation, consequently achieving an anti-inflammatory and highly phagocytic macrophage phenotype.(90) MSC(AD)s transferred the exosomes loaded with active STAT3 into macrophages ”
• Mitochondrial dysfunction: mechanisms and advances in therapy (2024, background): “418 These studies highlighted cell-dependent mitochondrial transfer as an extension of cell-based therapy.”