Fluorescence spectroscopy of neoplastic and non-neoplastic tissues.
By N. Ramanujam. Neoplasia, 2000
713 citations recorded by the source corpus.
Fast and non-invasive, diagnostic techniques based on fluorescence spectroscopy have the potential to link the biochemical and morphologic properties of tissues to individual patient care. One of the most widely explored applications of fluorescence spectroscopy is the detection of endoscopically invisible, early neoplastic growth in epithelial tissue sites. Currently, there are no effective diagnostic techniques for these early tissue transformations. If fluorescence spectroscopy can be applied successfully as a diagnostic technique in this clinical context, it may increase the potential for curative treatment, and thus, reduce complications and health care costs. Steady-state, fluorescence measurements from small tissue regions as well as relatively large tissue fields have been performed. To a much lesser extent, time-resolved, fluorescence measurements have also been explored for tissue characterization. Furthermore, sources of both intrinsic (endogenous fluorophores) and extrinsic fluorescence (exogenous fluorophores) have been considered. The goal of the current report is to provide a comprehensive review on steady-state and time-resolved, fluorescence measurements of neoplastic and non-neoplastic, biologic systems of varying degrees of complexity. First, the principles and methodology of fluorescence spectroscopy are discussed. Next, the endogenous fluorescence properties of cells, frozen tissue sections and excised and intact bulk tissues are presented; fluorescence measurements from both animal and human tissue models are discussed. This is concluded with future perspectives.
Subfields: Biomedical Engineering, Pulmonary and Respiratory Medicine, Radiology, Nuclear Medicine and Imaging
View Paper: https://www.semanticscholar.org/paper/c646b51685443115f932dad306f3d7ee20d403fd
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In Biomedical Engineering
In Pulmonary and Respiratory Medicine
In Radiology, Nuclear Medicine and Imaging
Citations in the corpus
- Tissue polarimetry: concepts, challenges, applications, and outlook. (2011, background): “81,82 In this context, polarization spectroscopy can offer several important advantages over the conventional polarization-blind measurements.”
- Medical hyperspectral imaging: a review (2014, background): “169 In vivo study: A combination of fluorescence and reflectance imaging has been shown to be able to interrogate the cervix tissue in vivo .”