Locally produced complement fragments C5a and C3a provide both costimulatory and survival signals to naive CD4+ T cells.

By Michael G. Strainic, Jinbo Liu, Danping Huang, F. An, P. Lalli, N. Muqim, V. Shapiro, G. Dubyak, P. Heeger, M. Medof. Immunity, 2008

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The Role of the Anaphylatoxins in Health and Disease (2009, positive): “Further, they not only described C3aR and C5aR expression on DCs and naïve, unstimulated CD4+ T cells but also found upregulation of both AT receptors upon antigen challenge (Strainic et al., 2008).”
Complement System Part II: Role in Immunity (2015, background): “In mice, resting T cells synthesize complement components constitutively, complement activation occurs in theirmicroenvironment, and the resultant C5a and C3a signaling, through the C5aR and C3aR, participates in cell viability bymaintaining the level of phosphorylated AKT (PKB), a T cell activation”
Sleep and immune function (2011, background): “Effects similar in direction are expected by increases in C3a produced by sleep [95], which exerts supportive influences on APC–T cell interactions, the production of IL-12 and the differentiation of Th cells towards a type 1 phenotype [112].”
The Complement System (2010, background): “Furthermore, APCs and T cells express C3aR and C5aR and locally produced C3a and C5a interact with their respective receptors and participate in maintaining T cell viability, proliferation and differentiation (Strainic et al. 2008; Lalli et al. 2008).”