Microglial activation and its implications in the brain diseases.

By S. Dheen, C. Kaur, E. Ling. Current Medicinal Chemistry, 2007

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Pax6 interacts with Iba1 and shows age-associated alterations in brain of aging mice. (2017, background): “They have been implicated in immunity of the brain (Nakanishi and sisodiyWu, 2009; Dheen et al., 2007), neurogenesis, homeostasis, neuro-inflammation and age-related neurological dysfunction (Sato, 2015; Grabert et al., 2016).”
Therapeutic application of histone deacetylase inhibitors for central nervous system disorders (2008, background): “Inflammation and apoptosis Studies of the neuroprotective roles of HDAC inhibitors, which are known to broadly affect gene expression within the immune system, have been extended to other diseases that involve inflammation and neuronal apoptosis, such as multiple sclerosi”