The role of T helper 17 (Th17) and regulatory T cells (Treg) in human organ transplantation and autoimmune disease

By B. Afzali, G. Lombardi, R. Lechler, Graham M Lord. Clinical and Experimental Immunology, 2007

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Inflammation in Fear- and Anxiety-Based Disorders: PTSD, GAD, and Beyond (2017, background): “Because T-reg cells are critical for containing pro-inflammatory responses and Th1 and Th17 cells activate inflammatory responses (Afzali et al, 2007), these alterations in the composition of T-cell subsets may act in aggregate to direct systemic inflammatory tone into an overdrive state in PTSD…”
AN INTERACTION BETWEEN KYNURENINE AND THE ARYL HYDROCARBON RECEPTOR CAN GENERATE REGULATORY T CELLS, (2010, background): “Interestingly, these new data have led investigators to question previously held beliefs about terminal cell differentiation and stability of Tregs, as the ability of Tregs to redifferentiate into Th17 cells in the appropriate inflammatory milieu has now been described (8, 9).”