A multiple testing correction method for genetic association studies using correlated single nucleotide polymorphisms

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Avoiding the high Bonferroni penalty in genome-wide association studies (2009, methodology): “…a large number of SNPs, e.g. 1M or 500K, are involved in the genetic association study, permutation tests become impractical for GWASs because it can take years to finish on a single modern PC if a substantial number of random shuffles are carried out [Conneely and Boehnke 2007; Gao, et al. 2008].”