Immunological aspects of intestinal mucus and mucins
By M. Johansson, G. Hansson. Nature reviews. Immunology, 2016
843 citations recorded by the source corpus.
A number of mechanisms ensure that the intestine is protected from pathogens and also against our own intestinal microbiota. The outermost of these is the secreted mucus, which entraps bacteria and prevents their translocation into the tissue. Mucus contains many immunomodulatory molecules and is largely produced by the goblet cells. These cells are highly responsive to the signals they receive from the immune system and are also able to deliver antigens from the lumen to dendritic cells in the lamina propria. In this Review, we will give a basic overview of mucus, mucins and goblet cells, and explain how each of these contributes to immune regulation in the intestine.
Subfields: Genetics, Molecular Biology, Surgery
View Paper: https://www.semanticscholar.org/paper/c5a76dde547ce4b3eb34fa51c8ba7d299411a02d
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Citations in the corpus
- The intestinal barrier: a fundamental role in health and disease (2017, background): “of themicrobiota as a gradient from the epithelium to the lumen, and show the highest concentrations in the small intestine where the mucus layer is less dense [10].”