Sarcopenia is associated with postoperative infection and delayed recovery from colorectal cancer resection surgery
By Jessica Lieffers, O. Bathe, K. Fassbender, M. Winget, Vickie E. Baracos. British Journal of Cancer, 2012
763 citations recorded by the source corpus.
Background:Skeletal muscle depletion (sarcopenia) predicts morbidity and mortality in the elderly and cancer patients.Methods:We tested whether sarcopenia predicts primary colorectal cancer resection outcomes in stage II–IV patients (n=234). Sarcopenia was assessed using preoperative computed tomography images. Administrative hospitalisation data encompassing the index surgical admission, direct transfers for inpatient rehabilitation care and hospital re-admissions within 30 days was searched for International Classification of Disease (ICD)-10 codes for postoperative infections and inpatient rehabilitation care and used to calculate length of stay (LOS).Results:Overall, 38.9% were sarcopenic; 16.7% had an infection and 9.0% had inpatient rehabilitation care. Length of stay was longer for sarcopenic patients overall (15.9±14.2 days vs 12.3±9.8 days, P=0.038) and especially in those ⩾65 years (20.2±16.9 days vs 13.1±8.3 days, P=0.008). Infection risk was greater for sarcopenic patients overall (23.7% vs 12.5%; P=0.025), and especially those ⩾65 years (29.6% vs 8.8%, P=0.005). Most (90%) inpatient rehabilitation care was in patients ⩾65 years. Inpatient rehabilitation was more common in sarcopenic patients overall (14.3% vs 5.6%; P=0.024) and those ⩾65 years (24.1% vs 10.7%, P=0.06). In a multivariate model in patients ⩾65 years, sarcopenia was an independent predictor of both infection (odds ratio (OR) 4.6, (95% confidence interval (CI) 1.5, 13.9) P<0.01) and rehabilitation care (OR 3.1 (95% CI 1.04, 9.4) P<0.04).Conclusion:Sarcopenia predicts postoperative infections, inpatient rehabilitation care and consequently a longer LOS.
Subfields: Geriatrics and Gerontology, Physiology, Surgery
View Paper: https://www.semanticscholar.org/paper/c522ecfa046aa3307c8564adcb74f10223d6f12b
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Citations in the corpus
- Measurement of skeletal muscle radiation attenuation and basis of its biological variation (2014, background): “Muscle wasting also associates with poor clinical outcomes in cancer patient populations, including mortality, treatment toxicity, post-operative infections and extended hospital stay (Lieffers et al. 2012).”
- Guidelines for Perioperative Care in Elective Colonic Surgery: Enhanced Recovery After Surgery (ERAS®) Society Recommendations (2012, background): “A recent study has demonstrated that the presence of low muscle mass is predictive of complications and LOSH after colorectal surgery [178].”