M2b macrophage polarization and its roles in diseases

By Lexun Wang, Shengxi Zhang, Huijuan Wu, X. Rong, Jiao Guo. Journal of Leukocyte Biology, 2018

719 citations recorded by the source corpus.

Macrophages play an important role in a wide variety of physiologic and pathologic processes. Plasticity and functional polarization are hallmarks of macrophages. Macrophages commonly exist in two distinct subsets: classically activated macrophages (M1) and alternatively activated macrophages (M2). M2b, a subtype of M2 macrophages, has attracted increasing attention over the past decade due to its strong immune‐regulated and anti‐inflammatory effects. A wide variety of stimuli and multiple factors modulate M2b macrophage polarization in vitro and in vivo. M2b macrophages possess both protective and pathogenic roles in various diseases. Understanding the mechanisms of M2b macrophage activation and the modulation of their polarization might provide a great perspective for the design of novel therapeutic strategies. The purpose of this review is to discuss current knowledge of M2b macrophage polarization, the roles of M2b macrophages in a variety of diseases and the stimuli to modulate M2b macrophage polarization.

Subfields: Immunology, Oncology

View Paper: https://www.semanticscholar.org/paper/c4fafedd0f7e14c16523438112813a03654e5083

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

1. Xiang-Hong Xu
2. Liping Jin
3. Yongli Yao

Citations in the corpus

• Macrophage Polarization in Physiological and Pathological Pregnancy (2019, background): “Based on the expression profiles of cytokines and chemokines, M2b macrophages regulate the breadth and depth of immune responses and inflammatory reactions (21).”