Extracellular matrix assembly: a multiscale deconstruction
By J. Mouw, Guanqing Ou, Valerie M. Weaver. Nature reviews. Molecular cell biology, 2014
1,332 citations recorded by the source corpus.
The biochemical and biophysical properties of the extracellular matrix (ECM) dictate tissue-specific cell behaviour. The molecules that are associated with the ECM of each tissue, including collagens, proteoglycans, laminins and fibronectin, and the manner in which they are assembled determine the structure and the organization of the resultant ECM. The product is a specific ECM signature that is comprised of unique compositional and topographical features that both reflect and facilitate the functional requirements of the tissue.
Subfields: Cell Biology, Genetics, Immunology and Allergy
View Paper: https://www.semanticscholar.org/paper/c4ed5fe48a6140ded26abfe99868c4e9849be7aa
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Citations in the corpus
- Targeting cancer stem cell pathways for cancer therapy (2020, background): “511, 512 At present, increasing evidence shows that the ECM is an integral part of stem cell niches that regulates the balance of stem cells in three different biological states: static, self-renewal, and differentiation.”
- Three-Dimensional in Vitro Cell Culture Models in Drug Discovery and Drug Repositioning (2018, background): “…these components regulate cell proliferation, differentiation, migration, survival, adhesion, as well as cytoskeletal organization and cell signaling in normal physiology and development and in many diseases such as fibrosis, cancer and genetic disorders (Bonnans et al., 2014; Mouw et al., 2014).”
- Role of Extracellular Matrix in Development and Cancer Progression (2018, methodology): “While collagen, proteoglycans, and hyaluronic acid comprise the major structural component of the ECM, laminins are one of the molecules that bridge the interaction gap between the cells and the ECM [15].”