Notch2 is preferentially expressed in mature B cells and indispensable for marginal zone B lineage development.

By Toshiki I. Saito, S. Chiba, M. Ichikawa, A. Kunisato, T. Asai, K. Shimizu, Tomoyuki Yamaguchi, G. Yamamoto, S. Seo, K. Kumano and 4 more. Immunity, 2003

640 citations recorded by the source corpus.

Subfields: Molecular Biology

View Paper: https://www.semanticscholar.org/paper/c4aa58df66db13b4ba71021f2f67cb60141475aa

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In Molecular Biology

1. George W. Wright
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Citations in the corpus

• Notch–RBP-J signaling controls the homeostasis of CD8− dendritic cells in the spleen (2007, background): “6) nor MZ B cells (26) express higher levels of Notch receptors compared with their Notch-independent counterparts such as CD8+ DCs and follicular B cells, respectively.”
• A Probabilistic Classification Tool for Genetic Subtypes of Diffuse Large B Cell Lymphoma with Therapeutic Implications (2020, background): “Mutations characteristic of BN2 link this subtype to marginalzone lymphomas (MZLs) (Figure 3E), befitting the essential role of NOTCH2 in the differentiation of follicular B cells to marginal zone B cells (Saito et al., 2003).”
• The follicular versus marginal zone B lymphocyte cell fate decision (2009, background): “Whereas Notch1 drives the development of αβ T cells at the expense of B cells, Notch2 is required for marginal zone B cell development during B cell maturation in the splee”