Modeling the therapeutic efficacy of p53 restoration in tumors.

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The tumor suppressor p53 regulates polarity of self-renewing divisions in mammary stem cells. (2009, background): “Therapeutic Efficacy of p53 Restoration in Cancer SCs Three groups have recently reported that re-expression of p53 causes regression of different p53 null tumors, including lymphomas, sarcomas, and hepatocellular carcinomas (Martins et al., 2006; Ventura et al., 2007; Xue et al., 2007).”
Principles of Cancer Therapy: Oncogene and Non-oncogene Addiction (2009, positive): “This concept has been recently demonstrated by reactivation of p53 in mouse tumor models (Martins et al., 2006; Ventura et al., 2007; Xue et al., 2007).”
Awakening guardian angels: drugging the p53 pathway (2009, background): “A series of genetic models has, however, established that the restoration of p53 activity in established tumour cells is an exceptionally effective interventio”
Blinded by the Light: The Growing Complexity of p53. (2009, background): “This approach is elegantly supported by animal studies where reactivation of wild-type p53 leads to efficient tumor regression (Martins et al., 2006; Ventura et al., 2007; Xue et al., 2007).”