The role of iron regulatory proteins in mammalian iron homeostasis and disease

By Tracey Rouault. Nature Chemical Biology, 2006

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Metalloproteins and metal sensing (2009, background): “Metal regulation of mRNA stability and translation In a highly parsimonious way, the iron-responsive proteins IRP1 (also known as ACO1) and IRP2 (IREB2) control translation or mRNA stability reciprocally for different gene product”
Siderophore-Based Iron Acquisition and Pathogen Control (2007, background): “The labile iron pool is permanently regulated via IRE/IRPdependent expression of the transferrin receptor and ferritin (283).”
Function and biogenesis of iron–sulphur proteins (2009, background): “When the protein loses its labile cluster under iron deprivation, it can bind to stem-loop structures (termed iron-responsive elements (IREs)) in certain messenger RNAs of proteins involved in iron uptake, storage and distribution in the cel”
The genetic basis of kidney cancer: a metabolic disease (2010, background): “(40;41) Overexpression of IRP1 suppresses growth of lung tumor xenografts, (42) which has prompted the search for small molecules that could decrease HIF2-α translation by enhancing the binding of IRP1 to the 5’ untranslated region of its mRNA.”